2-(2-BENZYLOXYPHENOXY)ETHYLAMINE synthesis

Yield:72955-81-8 81%

Reaction Conditions:

Stage #1: 2-(2-(benzyloxy)phenoxy)acetamidewith dimethylsulfide borane complex in tetrahydrofuran at 20;Inert atmosphere;Reflux;
Stage #2: with hydrogenchloride in tetrahydrofuran;water at 60; for 1 h;
Stage #3: with sodium hydroxide in water;

References:

Carrieri, Antonio;Piergentili, Alessandro;Bello, Fabio Del;Giannella, Mario;Pigini, Maria;Leonardi, Amedeo;Fanelli, Francesca;Quaglia, Wilma [Bioorganic and Medicinal Chemistry,2010,vol. 18,# 19,p. 7065 - 7077] Location in patent:experimental part