2-(2-BROMOPHENYL)-2-METHYLPROPAN-1-AMINE(WXG01973) synthesis

Yield:71095-49-3 4 g

Reaction Conditions:

with dimethylsulfide borane complex in tetrahydrofuran at 0; for 19 h;Reflux;

Steps:

103A 2-(2-Bromophenyl)-2-methylpropan-1-amine

To a solution of 2-(2- bromophenyl)-2-methylpropanenitrile (4.0 g, 17.8 mmol), in dry THF (40 mL) was added borane-dimethyl sulfide (5.08 mL, 53.5 mmol) at 0 °C and the reaction mixture was slowly brought to rt, stirred for 1 h and then, heated to reflux for 18 h. The solvent was removed and quenched with MeOH, and heated to reflux for 18 h. The reaction was concentrated and the residue was dissolved in EtOAc, washed with H₂O, brine, dried (Na₂SO₄), flltered and concentrated to give 4.0 g of 103 A as a white solid. MS (ESI) m/z: 230.2 (M+H)⁺.

References:

WO2013/56034,2013,A1 Location in patent:Paragraph 00303