2-[(2-Chloro-thiazol-5-ylMethyl)-aMino]-ethanol synthesis

Yield:1269145-75-6 80%

Reaction Conditions:

in N,N-dimethyl-formamide at 0 - 35;Cooling with ice;

Steps:

1

2-(((2-Chlorothiazol-5-yl)methyl)amino)ethanolUnder ice-water bath cooling and stirring,To the N,N-dimethylformamide (DMF, 50mL) solution of 2-amino·ethanol (0.25mol), slowly drip 2-chloro-5-chloromethylthiazole (0.10mol) and DMF (10mL) )'S mixed solution. After the addition is complete, the reaction is stirred at 0-35°C until complete. The reaction mixture was subjected to conventional post-treatment: adding ice brine, extracting with ethyl acetate, washing the organic phase with water, and drying the organic phase over anhydrous sodium sulfate, then removing the solvent under reduced pressure to obtain the crude title product. The crude product was purified by column chromatography. Pale yellow viscous liquid title material, the yield is greater than 80%.

References:

CN111662283,2020,A Location in patent:Paragraph 0194-0196