2-(2-Chlorophenyl)-1-phenylethan-1-ol synthesis
6synthesis methods
- Product Name:2-(2-Chlorophenyl)-1-phenylethan-1-ol
- CAS Number:53774-32-6
- Molecular formula:C14H13ClO
- Molecular Weight:232.71
Yield:53774-32-6 241 mg
Reaction Conditions:
Stage #1: 1-chloro-2-(chloromethyl)benzenewith indium(III) chloride;manganese;chloro-trimethyl-silane;palladium dichloride in tetrahydrofuran at 25; for 16 h;Inert atmosphere;
Stage #2: benzaldehyde in tetrahydrofuran at 0 - 25;Inert atmosphere;
Stage #3: with water;sodium chloride in tetrahydrofuran;Inert atmosphere;
References:
Peng, Zhihua;Knochel, Paul [Organic Letters,2011,vol. 13,# 12,p. 3198 - 3201] Location in patent:supporting information; experimental part