2-(2-Chlorophenyl)-2-methylpropionic acid synthesis

Yield:69849-06-5 27%

Reaction Conditions:

with potassium hydroxide in methanol;lithium hydroxide monohydrate; for 15 h;Heating / reflux;

Steps:

19

To a solution of 2.2 g (10 mmol) of the above ester in MEOH (60 mL) was added an aqueous solution OF KOH (60 mL of a 1.0 M solution). The reaction mixture was heated to reflux for 15 h. The mixture was cooled to room temperature and washed with Et2O then acidified to pH 2 with a solution OF 2N HC1. The aqueous layer was extracted with CH2CK, dried over anhydrous NA2S04 and concentrated under reduced pressure to provide 0.55 g (27%) of 2- (2- CHLOROPHENYL)-2-METHYL-PROPIONIC acid as a light brown solid. The crude reaction product was not purified but used immediately.

References:

WO2004/67516,2004,A1 Location in patent:Page 86 - 87