2,2-DibroMo-1-thiophen-2-yl-ethanone synthesis
- Product Name:2,2-DibroMo-1-thiophen-2-yl-ethanone
- CAS Number:68672-88-8
- Molecular formula:C6H4Br2OS
- Molecular Weight:283.97
4298-52-6
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$24.00/1g
57681-63-7
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inquiry
68672-88-8
19 suppliers
$150.00/0.5g
Yield:68672-88-8 28% ，57681-63-7 28%
Reaction Conditions:
with N-Bromosuccinimide;perchloric acid in water;acetonitrile at 20; for 12 h;Inert atmosphere;
Steps:
General procedure for the preparationof α,α-dibromoketones 5
General procedure: Acetonitrile (2 cm3/mmol), water (1 cm3/mmol), and HClO4 (10 mol %) was added to a mixture of alkyne 4(1.0 mmol) and NBS (2.5 mmol). The resultant mixture was stirred for the time indicated in Table 1. Then, thereaction mixture was diluted with Et2O (8 cm3/mmol) andwashed with a saturated solution of Na2CO3 (3 cm3/mmol),Na2S2O3 (3 cm3/mmol), water (3 cm3/mmol), and brine (3 cm3/mmol). The organic layer was dried over MgSO4,concentrated under reduced pressure and column chromatographyon silica gel afforded the a,a-dibromoketones 5.
References:
Kotek, Vladislav;Polk, Peter;Tobrman, Tom [Monatshefte fur Chemie,2016,vol. 147,# 2,p. 405 - 412]
872-55-9
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68672-88-8
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$150.00/0.5g
88-15-3
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$5.00/10g
68672-88-8
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2810-04-0
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$8.00/5g
74-95-3
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$10.00/10g
68672-88-8
19 suppliers
$150.00/0.5g
88-15-3
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$5.00/10g
10531-41-6
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$10.00/250mg
68672-88-8
19 suppliers
$150.00/0.5g