ChemicalBook CAS DataBase List 2,2-DICHLOROACETOPHENONE

2,2-DICHLOROACETOPHENONE synthesis

12synthesis methods

Product Name:2,2-DICHLOROACETOPHENONE
CAS Number:2648-61-5
Molecular formula:C8H6Cl2O
Molecular Weight:189.04

2170-06-1
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$11.00/1g

2648-61-5
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$55.00/5 g

Yield: 88%

Reaction Conditions:

with trichloroisocyanuric acid;p-methylphenylthiourea;water at 20; for 0.333333 h;Sealed tube;Sonication;Green chemistry;chemoselective reaction;

Steps:

4.1.1. General procedure for the synthesis of 2
General procedure: Procedure for 2: To a solution of alkyne (0.3 mmol) in water(1.5 mL) in sealed tube was added TXCA (0.3 mmol) and p-tolylthiourea (0.075 mmol, 12 mg), the reaction mixture was ultrasonic at room temperature under and the reaction was monitored by TLC. The reaction typically took 20 min. Upon completion, the mixturewas concentrated under reduced pressure.The residue was purified by column chromatography on silica gel(eluent: hexanes/ethyl acetate) to afford 2a - 2aa.

References:

Zhang, Xingyu;Wu, Yundong;Zhang, Ya;Liu, Huilan;Xie, Ziyu;Fu, Shengmin;Liu, Fang [Tetrahedron,2017,vol. 73,# 31,p. 4513 - 4518]

98-86-2 Synthesis