ChemicalBook CAS DataBase List 2,2-Dichloropropanoyl chloride

2,2-Dichloropropanoyl chloride synthesis

13synthesis methods

Product Name:2,2-Dichloropropanoyl chloride
CAS Number:26073-26-7
Molecular formula:C3H3Cl3O
Molecular Weight:161.41

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Yield:26073-26-7 92%

Reaction Conditions:

with thionyl chloride in N-methyl-acetamide;

Steps:

1.B B.

B. 2,2-Dichloropropionyl Chloride To a dry 100 mL 3-necked flask under nitrogen were added 2,2-dichloropropionic acid (50 g., 0.35 moles, 1 eq.) and dimethylformamide (4 mL, 0.05 moles, 0.15 eq.). Thionyl chloride (35 mL, 0.49 moles, 1.4 eq.) then was added dropwise over 30 minutes. The reaction mixture was warmed to 55° C. for two hours while being following by gas chromatography with methanol quench to insure disappearance of dichloropropionic acid (retention time 8.5 minutes). 2,2-dichloropropionyl chloride was distilled at 120°-121° C. to give 51.7 g. (92% yield) of a slightly yellow oil.

References:

US5424454,1995,A