2,2-diethoxy-ethanimidic acid methyl ester synthesis
- Product Name:2,2-diethoxy-ethanimidic acid methyl ester
- CAS Number:76742-48-8
- Molecular formula:C7H15NO3
- Molecular Weight:161.2
6136-93-2
139 suppliers
$10.00/1g
76742-48-8
39 suppliers
inquiry
Yield: 92%
Reaction Conditions:
with carbon dioxide;sodium methylate in methanol;diethyl ether
Steps:
236.a Preparation of Compound 236 in Table 7
a) To a solution of sodium methoxide (3.54 ml of a 25% wt. solution in methanol, 15.5 mmol) in methanol (80 ml) was added diethoxyacetonitrile (215 ml, 155 mmol) and the reaction mixture stirred for 4 hours at room temperature. Solid carbon dioxide was added and most of the methanol was removed in vacuo. Diethyl ether (30 ml) was added and the sodium carbonate removed by filtration. The residue was concentrated to afford methyl diethoxyacetimidate as a colourless oil (22 g, 92% yield) which was used with no further purification. MS (+ve ESI): 162 (M+H)+.
References:
AstraZeneca AB US7235559, 2007, B1
67-56-1
757 suppliers
$7.29/5ml-f
6136-93-2
139 suppliers
$10.00/1g
124-41-4
701 suppliers
$12.00/25g
76742-48-8
39 suppliers
inquiry