2,2-Difluoro-2-phenyl-ethanol synthesis

12synthesis methods

Product Name:2,2-Difluoro-2-phenyl-ethanol
CAS Number:129973-51-9
Molecular formula:C8H8F2O
Molecular Weight:158.15

2248-46-6 Synthesis

(ALPHA,ALPHA-DIFLUORO)PHENYLACETIC ACID ETHYL ESTER

2248-46-6
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129973-51-9
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Yield:129973-51-9 99%

Reaction Conditions:

with C₃₉H₅₃ClN₂P₂Ru;potassium methanolate;hydrogen in tetrahydrofuran at 20; under 38002.6 Torr; for 16 h;Glovebox;Autoclave;

Steps:

29 Example 29: Hydrogenation of ester compounds catalyzed by ruthenium complex Il at room temperature

General procedure: In a glove box, add a ruthenium complex Il (0.75 mg, 0.001 mmol),Potassium methoxide (3.5 to 70 mg, 0.05 to 1 mmol), tetrahydrofuran (1 to 10 mL), and ester compounds (0.5 to 10 mmol).After sealing the autoclave, remove it from the glove box and fill it with hydrogen to the required pressure.The reaction vessel was stirred at room temperature for 16 to 24 hours.After slowly releasing excess hydrogen, the reaction solution was depressurized to remove the solvent, and the residue was purified by a short column of silica gel to obtain an alcohol compound.The results are shown in Table 7.

References:

CN110357923,2019,A Location in patent:Paragraph 0312-0315