![](/CAS/GIF/373-96-6.gif)
2,2-Difluoropropionic acid synthesis
- Product Name:2,2-Difluoropropionic acid
- CAS Number:373-96-6
- Molecular formula:C3H4F2O2
- Molecular Weight:110.06
![Ethyl 2,2-Difluoropropionate](/CAS/GIF/28781-85-3.gif)
28781-85-3
200 suppliers
$15.00/1g
![2,2-Difluoropropionic acid](/CAS/GIF/373-96-6.gif)
373-96-6
214 suppliers
$13.00/1g
Yield:373-96-6 92%
Reaction Conditions:
with aqueous sodium hydroxide in ethanol;
Steps:
R.G.38 2,2-difluoropropionic acid
Reference Example G 38 2,2-difluoropropionic acid A solution of ethyl 2,2-difluoropropionate (1.2 g, 8.8 mmol) in ethanol (26 mL) was added to 2N aqueous sodium hydroxide (26 mL) and the resulting mixture was stirred at room temperature for 14 hours. The reaction mixture was acidified with 2N hydrochloric acid and extracted with ether. The extracts were dried, and concentrated under reduced pressure to give the title compound (0.90 g, yield 92%). oil 1H-NMR(CDCl3) d: 1.85 (3H, t, J= 19.0Hz), 6.21 (1H, br s).
References:
EP1402900,2004,A1
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![2,2-Difluoropropionic acid](/CAS/GIF/373-96-6.gif)
373-96-6
214 suppliers
$13.00/1g
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373-96-6
214 suppliers
$13.00/1g
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![2,2-Difluoropropionic acid](/CAS/GIF/373-96-6.gif)
373-96-6
214 suppliers
$13.00/1g