2,2-Dimethyl-1,3-benzoxazin-4-one synthesis

10synthesis methods

Product Name:2,2-Dimethyl-1,3-benzoxazin-4-one
CAS Number:30914-88-6
Molecular formula:C10H11NO2
Molecular Weight:177.2

77-76-9
389 suppliers
$9.00/5ml

65-45-2 Synthesis

65-45-2
536 suppliers
$5.00/25g

30914-88-6
25 suppliers
$95.00/500mg

Yield:30914-88-6 98%

Reaction Conditions:

in acetonitrile at 70; for 6 h;

Steps:

1; 2; 3 Compound 1: Preparation of 2,2-Dimethyl-2H-benzo[e][1,3]oxazine-4(3H)-one

Add 50 g of salicylamide, 300 mL of 2,2-dimethoxypropane, 300 mL of acetonitrile to the reaction flask, react at 70°C for 6 hours, concentrate to remove most of the solvent, filter the precipitated product, collect the filter cake, and dry to obtain compound 1:2 ,2-Dimethyl-2H-benzo[1,3]oxazine-4(3H)-one 63.2g, molar yield 98%, purity 99.8%.

References:

CN112898220,2021,A Location in patent:Paragraph 0076-0078; 0086-0088; 0095-0097