2-(2-FLUORO-PHENYL)-N-HYDROXY-ACETAMIDINE synthesis

Yield:872361-89-2 1.26 g

Reaction Conditions:

with hydroxyamino hydrochloride;triethylamine in ethanol; for 2 h;Reflux;

Steps:

6.3

6.3 1 ml of 2-fluorophenylacetonitrile and 3.3 ml of triethylamine are added to a suspension of 1.05 g of hydroxylammonium chloride in 16 ml of ethanol. The mixture is stirred under reflux for 2 h. The solution is evaporated and subjected to conventional work-up, giving 1.26 g of 2-(2-fluorophenyl)-N-hydroxyacetamidine

References:

US2013/245355,2013,A1 Location in patent:Paragraph 0274