2-(2-fluorophenyl)-1H-benzimidazole synthesis
- Product Name:2-(2-fluorophenyl)-1H-benzimidazole
- CAS Number:321-51-7
- Molecular formula:C13H9FN2
- Molecular Weight:212.22
Yield:321-51-7 92%
Reaction Conditions:
with sodium hydrogensulfite in water at 100; for 0.166667 h;Green chemistry;chemoselective reaction;
Steps:
General procedure for the synthesis of 2-substitutedbenzimidazole
General procedure: In a round-bottomed flask (10 mL) equipped with a magnetic stirrer, a mixture of aldehyde (1.0 mmol) and NaHSO3(11.0 eq, 1.14 g) in H2O (4.0 mL) was prepared. When the mixture reached refluxing temperature, o-phenylenediamine derivatives (1.0 mmol) were added. The resulting mixture was stirred for appropriate time and monitored by HPLC (Hypersil GOLD 250 × 4.6 mm, 5 μm). After completion of the reaction, the reaction mixture was vacuum filtered after cooling to room temperature by a glass funnel. The residues were washed by water (4 mL × 2), dried in air dry oven and characterized by physical and spectral properties.
References:
Jiang, Yu-Qin;Jia, Shu-Hong;Li, Xi-Yong;Sun, Ya-Min;Li, Wei;Zhang, Wei-Wei;Xu, Gui-Qing [Chemical Papers,2018,vol. 72,# 5,p. 1265 - 1276]
1072-85-1
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321-51-7
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