2-(2-Methylpropyl)phenol synthesis

14synthesis methods

Product Name:2-(2-Methylpropyl)phenol
CAS Number:4167-75-3
Molecular formula:C10H14O
Molecular Weight:150.22

20944-88-1
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4167-75-3
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Yield:4167-75-3 99%

Reaction Conditions:

with hydrogen;nickel in methanol at 60; under 45004.5 Torr; for 24 h;

Steps:

Hydrogenation was performed utilizing an H-CubeTM at apressure of 60 bar at 60 C with a Raney-Ni powdercartridge (THS 01112). A solution of 3.50 g 2 (23.6 mmol)in 250 cm3 MeOH (*0.1 M) was used in continuous flowmode of 1.0 cm3/min. The hydrogenation was run in a loopuntil full conversion was detected by GC-MS (24 h). Afterremoving the solvent under reduced pressure, 3.51 g(99 %) 3 was isolated as colorless oil. An analyticalsample was purified by distillation. B.p. 45 C/0.3 mbar(Ref. [44]; 45-50 C/1.3 mbar); NMR data were found toagree with those described in Ref. [32].

References:

Trobe, Melanie;Breinbauer, Rolf [Monatshefte fur Chemie,2016,vol. 147,# 3,p. 509 - 521]