2-(2-Naphthyl)acetyl chloride synthesis
- Product Name:2-(2-Naphthyl)acetyl chloride
- CAS Number:37859-25-9
- Molecular formula:C12H9ClO
- Molecular Weight:204.65
581-96-4
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Yield: 99%
Reaction Conditions:
with oxalyl dichloride;N,N-dimethyl-formamide in dichloromethane at 20; for 3 h;
Steps:
14.1
Oxalyl chloride (7.0 mL, 80.2 mmol)was added under nitrogen to a solution of 2-naphthylacetic acid (3.00 g, 16.1 mmol) in 150 mL of methylene chloride at room temperature. A catalytic amount of DMF (10 uL) was added andthe R£tiln''sMilQ iic^eliprSttie for 3 h. The solvent and excess oxalyl chloride were removed under reduced pressure. To remove any residual oxalyl chloride the residue was taken up in benzene and then concentrated under reduced pressure to give naphthalen-2-yl-acetyl chloride (3.20 g, 99%) as a yellow solid that was used in the next step without additional purification.
References:
WYETH WO2006/23865, 2006, A1 Location in patent:Page/Page column 48-49
93579-03-4
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![Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-](/CAS/20210305/GIF/1000210-73-0.gif)
1000210-73-0
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37859-25-9
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93-08-3
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37859-25-9
81 suppliers
$28.00/250mg