2,2'-(P-TOLYLIMINO)DIETHANOL synthesis
- Product Name:2,2'-(P-TOLYLIMINO)DIETHANOL
- CAS Number:3077-12-1
- Molecular formula:C11H17NO2
- Molecular Weight:195.26
Yield:3077-12-1 94 %
Reaction Conditions:
with cobalt(II) bromide;zinc in dimethyl sulfoxide at 80;Inert atmosphere;
Steps:
3 Synthesis of N,N'-bis(2-hydroxyethyl)-4-methylaniline (formula 3):
Under nitrogen atmosphere, add anhydrous cobalt(II) bromide [3.3mg, 0.015mmol], zinc powder (49mg, 0.75mmol), solvent DMSO (1mL), 4-nitrotoluene to a dry 25mL reaction flask in sequence (68.6mg, 0.5mmol), 2-chloroethanol (105 μL, 1.5mmol).React for 6 hours on a heater with a rotating speed of 100rpm and 80°C. The reaction of the raw materials is detected by TLC, and the reaction is stopped. The reaction mixture is extracted with distilled water and ethyl acetate several times, and the organic phases are combined and dried with anhydrous sodium sulfate. , concentrated the organic phase, and then subjected to column chromatography with the eluent (ethyl acetate/petroleum ether=5/1) to obtain 91.8 mg of the product as a light yellow liquid with a yield of 94%.
References:
CN115073311,2022,A Location in patent:Paragraph 0041-0045
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