2-(2-PhthaliMidoethoxy)acetic acid, 97% synthesis

5synthesis methods

Product Name:2-(2-PhthaliMidoethoxy)acetic acid, 97%
CAS Number:69676-65-9
Molecular formula:C12H11NO5
Molecular Weight:249.22

69676-63-7 Synthesis

2-(2-(2-hydroxyethoxy)ethyl)isoindoline-1,3-dione

69676-63-7
53 suppliers
$45.00/50mg

69676-65-9
10 suppliers
$101.22/1g

Yield:69676-65-9 96.5%

Reaction Conditions:

with TEMPOL;copper(II) nitrate trihydrate;oxygen in 1,2-dichloro-ethane at 20;Catalytic behavior;Sealed tube;Reagent/catalyst;Temperature;Solvent;

Steps:

1

General procedure: Add 1 mol of 2-(2-(2-hydroxyethoxy)ethyl)isoindoline-1,3-dione (compound 1), N-O free radical catalyst,Metal salt catalyst, reaction solvent (reaction flask connected to liquid sealing tube),And continue to pass in air or oxygen,The reaction is carried out under certain temperature conditions; as the reaction proceeds,A white solid is continuously precipitated in the system. After the reaction is complete (TLC monitors the end of the reaction), it is filtered, and the filtrate is distilled and recovered for reuse;The filter cake is washed with reaction solvent and dried under vacuum at room temperature.A white powdery solid product was obtained.

References:

CN111620806,2020,A Location in patent:Paragraph 0066-0080