2-(2-Pyridinyl)benzaldehyde synthesis
- Product Name:2-(2-Pyridinyl)benzaldehyde
- CAS Number:863677-33-2
- Molecular formula:C12H9NO
- Molecular Weight:183.21
109-09-1
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Yield:863677-33-2 79%
Reaction Conditions:
with C46H49BrClFeN3Pd;copper diacetate;caesium carbonate in 1,4-dioxane at 110; for 24 h;Suzuki Coupling;
Steps:
2.4. General procedure for the one-pot oxidation/Suzuki coupling
General procedure: A 10 mL round-bottom flask was charged with the prescribedamount of catalyst Pd/Cu, aryl chlorides (0.5 mmol), phenylboronicacids containing hydroxymethyl (0.75 mmol), Cs2CO3 (1.0 mmol)and dioxane (5 mL) in air. The reaction mixture was then placedin an oil bath and heated at 110 C for 24 h. After removal of thesolvent, the resulting residue was purified by flash chromatographyon silica gel using CH2Cl2 as eluent. The products 4a-k, and4m are known compounds [6,9] except for 4l and 4n.
References:
Xu, Chen;Li, Hong-Mei;Wang, Zhi-Qiang;Fu, Wei-Jun [Inorganica Chimica Acta,2014,vol. 423,# PART A,p. 11 - 15]
