2-(2-THIENYL)-1,2,3-TRIHYDROQUINAZOLIN-4-ONE synthesis
- Product Name:2-(2-THIENYL)-1,2,3-TRIHYDROQUINAZOLIN-4-ONE
- CAS Number:13324-83-9
- Molecular formula:C12H10N2OS
- Molecular Weight:230.29
Yield:13324-83-9 99%
Reaction Conditions:
with yttrium tris(trifluoromethanesulfonate) in ethanol at 20; for 1.5 h;
Steps:
2.1 A general procedure for preparation of dihydroquinazolinones 3
General procedure: Y(OTf)3 (0.0268 g, 0.05 mmol) were dissolved in 10mL EtOH and stirred until the solid dissolved completely, then anthranilamide 1a (0.1498 g, 1.1 mmol) and benzaldehyde 2a (0.101 mL, 1.0 mmol) was added into the reaction mixture. After 1.5 h, TLC showed the reaction to be complete. Water (15 mL) was added to the reaction mixture, and the crystalline products were collected by filtration to give the crude product. The crude products thus obtained were crystallized from EtOH to give pure products 3a.
References:
Shang, Ying-Hui;Fan, Li-Yan;Li, Xiang-Xiong;Liu, Meng-Xia [Chinese Chemical Letters,2015,vol. 26,# 11,p. 1355 - 1358] Location in patent:supporting information
