ChemicalBook CAS DataBase List 2,3,4,5,6-PENTAMETHYLBENZYL CHLORIDE

2,3,4,5,6-PENTAMETHYLBENZYL CHLORIDE synthesis

11synthesis methods

Product Name:2,3,4,5,6-PENTAMETHYLBENZYL CHLORIDE
CAS Number:484-65-1
Molecular formula:C12H17Cl
Molecular Weight:196.72

484-66-2 Synthesis

484-66-2
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$16.60/1g

484-65-1
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$120.00/5 g

Yield: 100 %Spectr.

Reaction Conditions:

with chloro-trimethyl-silane in dichloromethane;water at 20; for 0.666667 h;

Steps:

A Representative Procedure for the Chlorination of 1a with TMSCl in the Presence of Na-Mont
General procedure: In a flask was placed Na-Mont (30 mg), 1a (1 mmol, 0.18 g),TMSCl (2 mmol, 0.22 g, 0.25 mL), and CH2Cl2 (5 mL). The mixture was stirred at r.t. for 40 min. The solid material was filtered off, and the filtrate was concentrated. Compound 3a was isolated by Kugelrohr distillation under vacuum in 90% yield as a colorless liquid.

References:

Tandiary, Michael Andreas;Masui, Yoichi;Onaka, Makoto [Synlett,2014,vol. 25,# 18,art. no. ST-2014-U0641-L,p. 2639 - 2643] Location in patent:supporting information

50-00-0 Synthesis