ChemicalBook CAS DataBase List 2,3,4,5-TETRAHYDRO-1H-BENZO[B][1,4]DIAZEPINE

2,3,4,5-TETRAHYDRO-1H-BENZO[B][1,4]DIAZEPINE synthesis

4synthesis methods

Product Name:2,3,4,5-TETRAHYDRO-1H-BENZO[B][1,4]DIAZEPINE
CAS Number:6516-89-8
Molecular formula:C9H12N2
Molecular Weight:148.21

5755-07-7 Synthesis

1,3,4,5-TETRAHYDRO-2H-1,5-BENZODIAZEPIN-2-ONE

5755-07-7
51 suppliers
$61.00/100mg

2,3,4,5-TETRAHYDRO-1H-BENZO[B][1,4]DIAZEPINE

6516-89-8
39 suppliers
$175.00/1 g

Yield:6516-89-8 73.9%

Reaction Conditions:

with dimethylsulfide borane complex in tetrahydrofuran at 60; for 5 h;

Steps:

2.7 2.7 Preparation of Compound B20
2.7 Preparation of Compound B20 To a solution of compound 2 (3.3 g, 20 mmol) in THF (50 mL) was added BH₃-Me₂S (3 mL, 30 mmol). The mixture was heated to 60° C. for 5 h. The mixture was concentrated in vacuo. The residue was purified by silica gel chromatography (PE:EA=1:1) to give B20 as yellow solid (2.1 g, yield: 73.9%). ¹H NMR (400 MHz, CDCl₃): δ ppm: 6.85-6.71 (m, 4H), 3.09-2.97 (m, 4H), 1.95-1.86 (m, 2H). LCMS: 149 [M+1].

References:

Hartman, George D. US2015/132258, 2015, A1 Location in patent:Paragraph 0352; 0355; 0356

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1336-21-6 Synthesis