![](/CAS/GIF/6516-89-8.gif)
2,3,4,5-TETRAHYDRO-1H-BENZO[B][1,4]DIAZEPINE synthesis
- Product Name:2,3,4,5-TETRAHYDRO-1H-BENZO[B][1,4]DIAZEPINE
- CAS Number:6516-89-8
- Molecular formula:C9H12N2
- Molecular Weight:148.21
![1,3,4,5-TETRAHYDRO-2H-1,5-BENZODIAZEPIN-2-ONE](/CAS/GIF/5755-07-7.gif)
5755-07-7
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$61.00/100mg
![2,3,4,5-TETRAHYDRO-1H-BENZO[B][1,4]DIAZEPINE](/CAS/GIF/6516-89-8.gif)
6516-89-8
39 suppliers
$175.00/1 g
Yield:6516-89-8 73.9%
Reaction Conditions:
with dimethylsulfide borane complex in tetrahydrofuran at 60; for 5 h;
Steps:
2.7 2.7 Preparation of Compound B20
2.7 Preparation of Compound B20 To a solution of compound 2 (3.3 g, 20 mmol) in THF (50 mL) was added BH3-Me2S (3 mL, 30 mmol). The mixture was heated to 60° C. for 5 h. The mixture was concentrated in vacuo. The residue was purified by silica gel chromatography (PE:EA=1:1) to give B20 as yellow solid (2.1 g, yield: 73.9%). 1H NMR (400 MHz, CDCl3): δ ppm: 6.85-6.71 (m, 4H), 3.09-2.97 (m, 4H), 1.95-1.86 (m, 2H). LCMS: 149 [M+1].
References:
Hartman, George D. US2015/132258, 2015, A1 Location in patent:Paragraph 0352; 0355; 0356
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1336-21-6
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$14.56/250ML
![1,3,4,5-TETRAHYDRO-2H-1,5-BENZODIAZEPIN-2-ONE](/CAS/GIF/5755-07-7.gif)
5755-07-7
51 suppliers
$61.00/100mg
![2,3,4,5-TETRAHYDRO-1H-BENZO[B][1,4]DIAZEPINE](/CAS/GIF/6516-89-8.gif)
6516-89-8
39 suppliers
$175.00/1 g
![4,5-dihydro-1-methyl-1H-benzo[b][1,4]diazepin-2(3H)-one](/CAS/20180703/GIF/384832-05-7.gif)
384832-05-7
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![2,3,4,5-TETRAHYDRO-1H-BENZO[B][1,4]DIAZEPINE](/CAS/GIF/6516-89-8.gif)
6516-89-8
39 suppliers
$175.00/1 g
![o-Phenylenediamine](/CAS/GIF/95-54-5.gif)
95-54-5
498 suppliers
$9.00/1g
![2,3,4,5-TETRAHYDRO-1H-BENZO[B][1,4]DIAZEPINE](/CAS/GIF/6516-89-8.gif)
6516-89-8
39 suppliers
$175.00/1 g