ChemicalBook CAS DataBase List 2,3,5,6-TETRAFLUORO-4-AMINOBENZOTRIFLUORIDE

2,3,5,6-TETRAFLUORO-4-AMINOBENZOTRIFLUORIDE synthesis

9synthesis methods

Product Name:2,3,5,6-TETRAFLUORO-4-AMINOBENZOTRIFLUORIDE
CAS Number:651-83-2
Molecular formula:C7H2F7N
Molecular Weight:233.09

434-64-0
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$6.00/1g

2,3,5,6-TETRAFLUORO-4-AMINOBENZOTRIFLUORIDE

651-83-2
88 suppliers
$25.00/1 g

Yield: 93%

Reaction Conditions:

with ammonia at 20; for 6 h;Autoclave;

Steps:

4.2.1. 2,3,5,6-Tetrafluoro-4-(trifluoromethyl)aniline (7)
1,2,3,4,5-Pentafluoro-6-(trifluoromethyl)benzene (50 g, 0.3 mol) and liquid ammonia were placed into the autoclave (volumetric capability 0.1 L). The reaction mixture was stirred at room temperature (r.t.) for 6 h. After completion of ammonia evaporation, H2O (50 mL) was added to the residue. The reaction product was separated by steam distillation. The distillate was extracted with CH2Cl2 (2100 mL) and dried (MgSO4). After evaporation of the solvent in vacuo, the title product (47 g, 93 %) was obtained as colorless liquid (the 1H and 19F NMR spectra agree well with the literature data [35].

References:

Politanskaya, Larisa V.;Shteingarts, Vitalij D.;Tretyakov, Evgeny V. [Journal of Fluorine Chemistry,2016,vol. 188,p. 85 - 98]