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109346-95-4

2-(3,5-dichlorophenyl)acetaldehyde synthesis

3synthesis methods
-

Yield:109346-95-4 60%

Reaction Conditions:

Stage #1: 2-(3,5-dichlorophenyl)acetic acidwith borane tetrahydrofuran in tetrahydrofuran at 0 - 20; for 3 h;
Stage #2: with Dess-Martin periodane in dichloromethane at 0 - 20; for 1 h;Dess-Martin Oxidation;

References:

Zhang, Yinan;Zhao, Kevin Tianmeng;Fox, Susan G.;Kim, Jinho;Kirsch, Donald R.;Ferrante, Robert J.;Morimoto, Richard I.;Silverman, Richard B. [Journal of Medicinal Chemistry,2015,vol. 58,# 15,p. 5942 - 5949]