2-(3,5-DIMETHYL-1H-PYRAZOL-1-YL)ACETOHYDRAZIDE synthesis
- Product Name:2-(3,5-DIMETHYL-1H-PYRAZOL-1-YL)ACETOHYDRAZIDE
- CAS Number:64019-58-5
- Molecular formula:C7H12N4O
- Molecular Weight:168.2
10199-60-7
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Yield:64019-58-5 87%
Reaction Conditions:
with hydrazine hydrate in ethanol; for 3 h;Reflux;
Steps:
5.1.2 General procedures for the preparation of 4a-c
General procedure: To a mixture of the appropriate 3a-c (5 mmol) in ethanol, hydrazine hydrate (5 mmol, 100%) was added dropwise with continuous stirring. The reaction mixture was then refluxed for 3 h and allowed to cool to room temperature. The separated product was filtered, dried and crystallized from ethanol. Yields for compounds 4a, b, and c were 87, 85, and 85% and m.p. were 189-190, 164-167, 196-197°C respectively.
References:
Marzouk, Adel A.;Taher, Ehab S.;Shaykoon, Montaser Sh. A.;Lan, Ping;Abd-Allah, Walaa Hamada;Aboregela, Adel M.;El-Behairy, Mohammed Farrag [Bioorganic Chemistry,2021,vol. 111,art. no. 104883]
67-51-6
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123-54-6
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64019-58-5
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