2-[(3-Amino-5-bromopyridin-2-yl)amino]ethanol synthesis

Yield:1216024-64-4 100%

Reaction Conditions:

with hydrazine hydrate in methanol at 20;

Steps:

322

I-102 (3.2 g, 12.3 mmol) and NH₂NH₂.H₂O (2.5 g, 49 mmol) were dissolved MeOH (40 mL) and the reaction mixture was stirred at room temperature while a suspension of Raney Ni was being added slowly. The reaction mixture was stirred for 1 hour at room temperature and filtered through a short plug of Celite, the filtrate was dried over Na₂SO₄, the solids were filtered and the filtrate was concentrated to give I-103 (2.8 g, 100%). MS (ESI): m/z 233 (M+1)⁺.

References:

US2010/204214,2010,A1 Location in patent:Page/Page column 117