ChemicalBook CAS DataBase List 2-(3-AMINO-PHENYL)-BENZOOXAZOL-5-YLAMINE

2-(3-AMINO-PHENYL)-BENZOOXAZOL-5-YLAMINE synthesis

7synthesis methods

Product Name:2-(3-AMINO-PHENYL)-BENZOOXAZOL-5-YLAMINE
CAS Number:13676-47-6
Molecular formula:C13H11N3O
Molecular Weight:225.25

1037-39-4
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2-(3-AMINO-PHENYL)-BENZOOXAZOL-5-YLAMINE

13676-47-6
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$23.00/250mg

Yield:13676-47-6 95%

Reaction Conditions:

with phosphoric acid;sodium sulfite in water at 100; pH=< 1; for 16 h;

Steps:

2 n the compound having the structure represented by the formula (I), R is a structure represented by the formula (2), and 2-(4-nitrophenyl)-5-nitrobenzoxazole is obtained.

At room temperature,Add 2-(4-nitrophenyl)-5-nitrobenzoxazole (3.22 g, to a 100 mL ml single-necked flask, 0.01 mol) and 50 mL of water,Adding phosphoric acid,Adjust the pH below 1.JoinSodium thiosulfitesolidbody(8.5g, 0.06mol),Warming up to 100 ° C,Continuous reaction for 16 h.After going to room temperature,filter,The filtrate was neutralized to a pH of 7 by adding a 25 wt% aqueous solution of sodium carbonate.The product precipitates from the reaction system,filter,Washed many times,dry,2.14 g of the product 2-(4-aminophenyl)-5-aminobenzoxazole were obtained (yield 95%, purity (HPLC) >99.9%).

References:

CN108558770,2018,A Location in patent:Paragraph 0082; 0083; 0084

7518-70-9 Synthesis