ChemicalBook CAS DataBase List 2-(3-CHLOROPHENOXY)ETHANETHIOAMIDE

2-(3-CHLOROPHENOXY)ETHANETHIOAMIDE synthesis

6synthesis methods

Product Name:2-(3-CHLOROPHENOXY)ETHANETHIOAMIDE
CAS Number:35370-95-7
Molecular formula:C8H8ClNOS
Molecular Weight:201.67

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Yield:35370-95-7 75.5%

Reaction Conditions:

with tetraphosphorus decasulfide in tetrahydrofuran at 50; for 1.5 h;

Steps:

3.3. Synthesis of the compound 4 series

General procedure: Compounds 3 (20 mmol) were dissolved in tetrahydrofuran (5 mL) in a 50 mL flask, then the solution was heated up to 50 °C slowly, phosphorus pentasulfide (40 mmol) was added in batches and stirred for 1.5 h at the same temperature. After cooling to room temperature, the reaction solution was poured to a beaker with 100 mL mixture of ice-cold water standing for another 2 h. And then it was extracted with ethyl acetate for 3 times, the organic phase was evaporated to obtain the crude product. Compounds 4 were yielded by dissolving the crude product in hot ethyl acetate, filtering while hot, and the solvent evaporating at reduced pressure.

References:

Li, Ting;Liu, Guyue;Li, Hongcai;Yang, Xinmei;Jing, Yongkui;Zhao, Guisen [Bioorganic and Medicinal Chemistry,2012,vol. 20,# 7,p. 2316 - 2322] Location in patent:experimental part

108-43-0 Synthesis