2,3-DICHLORO-4-FLUOROPHENOL synthesis
- Product Name:2,3-DICHLORO-4-FLUOROPHENOL
- CAS Number:934180-45-7
- Molecular formula:C6H3Cl2FO
- Molecular Weight:180.99
Yield:2995-06-4 42% ，934180-45-7 25%
Reaction Conditions:
with N-chloro-succinimide;trifluoroacetic acid in acetonitrile at 20; for 72 h;
Steps:
3-Chloro-4-fluorophenol (500 mg, 3.4mmol) was dissolved in acetonitrile (25 mL) and trifluoroacetic acid (500 mL) was added, followed by addition of λ/-chlorosuccinimide (456 mg, 3.4 mmol). The reaction was stirred at ambient temperature for 3 days and the volatiles were then removed in vacuo. The crude product was purified by chromatography on silica gel with EtOAc:isohexane (1 :19, v/v) as eluent to afford of 3,6-dichloro-4- fluorophenol (261 mg, 1.4mmol, 42%) and 2,3-dichloro-4-fluorophenol (153mg, O.δmmol, 25%).
References:
WO2007/39563,2007,A1 Location in patent:Page/Page column 23
2613-23-2
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