2,3-DIFLUORO-4-(TRIFLUOROMETHYL)BENZOIC ACID synthesis
- Product Name:2,3-DIFLUORO-4-(TRIFLUOROMETHYL)BENZOIC ACID
- CAS Number:237424-17-8
- Molecular formula:C8H3F5O2
- Molecular Weight:226.1
124-38-9
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237424-17-8
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$25.00/500mg
Yield:237424-17-8 84%
Reaction Conditions:
with 18-crown-6 ether;sodium fluoride;cesium fluoride at 180; under 750.075 Torr; for 5 h;
Steps:
2 Small test preparation of the target product:
18.2g (0.10mol) of 2,3-difluoro-trifluorotoluene, 15g (0.1mol) of cesium fluoride, 100g of DMI, 2g of 18-crown ether-6 catalyst, 14g of sodium tert-butoxide were heated and stirred in the 500mL reactor. , set the carbon dioxide bubbling pressure to 0.1MP, heat up to 180°C for reaction 5h, cool down, recover DMI under reduced pressure, the recovery rate is 95%, add 50mL of water, adjust pH=2, stir and crystallize, and suction filtration to obtain >98% of the target 2,3-difluoro-4-trifluoromethylbenzoic acid 20 g, yield 84%.
References:
CN114805050,2022,A Location in patent:Paragraph 0028-0032
64248-59-5
142 suppliers
$9.00/1g
237424-17-8
39 suppliers
$25.00/500mg