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ChemicalBook CAS DataBase List 2,3-DIFLUORO-6-METHOXYBENZYLAMINE

2,3-DIFLUORO-6-METHOXYBENZYLAMINE synthesis

2synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 3 steps
1.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -70 °C / Inert atmosphere
1.2: 1 h / -70 °C
2.1: hydroxylamine hydrochloride; sodium hydroxide / methanol; water / 3 h / 20 °C
3.1: ammonium hydroxide; hydrogen / methanol / 16 h / 20 °C

References:

WO2017/221092,2017,A1

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