2,3-DIFLUORO-6-NITROTOLUENE synthesis
- Product Name:2,3-DIFLUORO-6-NITROTOLUENE
- CAS Number:914348-35-9
- Molecular formula:C7H5F2NO2
- Molecular Weight:173.12
141428-47-9
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932373-72-3
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914348-35-9
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Yield:-
Reaction Conditions:
with potassium carbonate in N,N-dimethyl-formamide at 50; for 0.5 h;
Steps:
17
The mixture of 2,3-difluoro-4-nitrophenylacetic acid and 2,3-difluoro-6-nitrophenylacetic acid from D16 (13.5g) was dissolved in dimethylformamide (100ml) and potassium carbonate (8.5g) added. After stirring at 5O0C for 30min the cooled solution was partitioned between aqueous hydrochloric acid and hexane. Drying (MgSO4), evaporation, and chromatography (0-5% ethyl acetate in hexane, 7Og silica column) gave 3.2g of a 3:1 mixture of the title compound and 2,3-difluoro-6-nitrotoluene. EPO
References:
GLAXO GROUP LIMITED WO2007/36715, 2007, A2 Location in patent:Page/Page column 48-49