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2,3-DIHYDRO-1,4-BENZODIOXINE-6-CARBOHYDRAZIDE synthesis

5synthesis methods
20197-75-5 Synthesis
2,3-dihydro-1,4-benzodioxine -6-carboxylic acid methyl ester

20197-75-5
75 suppliers
$27.00/250mg

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Yield:98953-13-0 75%

Reaction Conditions:

with hydrazine hydrate in ethanol; for 48 h;Reflux;

References:

Lo Monte, Fabio;Kramer, Thomas;Gu, Jiamin;Anumala, Upendra Rao;Marinelli, Luciana;La Pietra, Valeria;Novellino, Ettore;Franco, Bénédicte;Demedts, David;Van Leuven, Fred;Fuertes, Ana;Dominguez, Juan Manuel;Plotkin, Batya;Eldar-Finkelman, Hagit;Schmidt, Boris [Journal of Medicinal Chemistry,2012,vol. 55,# 9,p. 4407 - 4424] Location in patent:experimental part