![953408-82-7](/CAS/GIF/953408-82-7.gif)
2,3-DIHYDRO-1-BENZOFURAN-7-SULFONYL CHLORIDE synthesis
- Product Name:2,3-DIHYDRO-1-BENZOFURAN-7-SULFONYL CHLORIDE
- CAS Number:953408-82-7
- Molecular formula:C8H7ClO3S
- Molecular Weight:218.66
![2,3-Dihydrobenzofuran](/CAS/GIF/496-16-2.gif)
496-16-2
378 suppliers
$7.00/5g
![2,3-DIHYDRO-1-BENZOFURAN-7-SULFONYL CHLORIDE](/CAS/GIF/953408-82-7.gif)
953408-82-7
19 suppliers
$60.00/10mg
Yield:953408-82-7 94%
Reaction Conditions:
in 1,2-dichloro-ethane;
Steps:
1 Preparation of 7-chlorosulfonyl-2,3-dihydrobenzo[b]furan (2)
Example 1 Preparation of 7-chlorosulfonyl-2,3-dihydrobenzo[b]furan (2) 2,3-Dihydrobenzo[b]furan (1) (Aldrich, 5.6 mL, 50 mmol) was added to a suspension of sulfur trioxide-dimethylformamide complex (Aldrich, 9.2 g, 60 mmol) in 1,2-dichloroethane (Aldrich, 20 mL). After being heated at 80° C. for 1 hour, the reaction mixture was cooled to room temperature, and thionyl chloride (Aldrich, 4.5 mL, 57 mmol) was introduced. The reaction mixture was then heated at 70° C. for 3 hours. After cooling down to room temperature, the reaction mixture was poured into ice water (100 mL) which was extracted with ether (3*30 mL). Combined organic layers were washed with brine, then dried (MgSO4). Removal of solvent under vacuum yielded a light yellow solid (10.2 g, 94%). TLC Rf 0.45 (9:1 of hexane-ethyl acetate); MS (electrospray) 219 (M+1); 1H NMR (CDCl3) δ3.35 (t, 2H, J=7.2 Hz), 4.78 (t, 2H, J=7.2 Hz), 6.92 (d, 1H, J=3.1 Hz), 7.82 (s, 1H), 7.83 (d, 1H, J=3.1 Hz).
References:
US6541467,2003,B1
![1,3-dibromo-2-(2-bromoethoxy)benzene](/CAS2/GIF/206347-32-2.gif)
206347-32-2
22 suppliers
$185.40/1g
![2,3-DIHYDRO-1-BENZOFURAN-7-SULFONYL CHLORIDE](/CAS/GIF/953408-82-7.gif)
953408-82-7
19 suppliers
$60.00/10mg
![7-BROMO-2,3-DIHYDRO-1-BENZOFURAN](/CAS/GIF/206347-30-0.gif)
206347-30-0
81 suppliers
$25.00/100mg
![2,3-DIHYDRO-1-BENZOFURAN-7-SULFONYL CHLORIDE](/CAS/GIF/953408-82-7.gif)
953408-82-7
19 suppliers
$60.00/10mg