2,3-Dihydro-4-trichloroacetylfuran synthesis

Yield:83124-80-5 86.08 %

Reaction Conditions:

with pyridine in dichloromethane at 0 - 25;Reagent/catalyst;Temperature;

Steps:

1.1; 2-7; 1; 15.1; 16.1 (1) Synthetic compound 2

Add 200ml of dichloromethane, 20g of compound 1 (2,3-dihydrofuran, 285.34mmol, 1eq) to the reaction flask, control the temperature at 0 °C, then add 77.82g of trichloroacetylchloride (428mmol, 1.5eq), then control the temperature at 0 °C, add 45.14 g pyridine (570.69mmol, 2eq), add it, rise to 25 °C, and react for 3h; After the reaction, the reaction solution was poured into 500ml of dichloromethane, and then washed twice with 1M dilute hydrochloric acid (200ml*2), the organic phase obtained by separating was washed once with 200ml saturated sodium bicarbonate solution, and finally the organic phase was washed once with 200ml saturated saline, and the organic phase obtained by separating again was dried, filtered, and spundried with anhydrous sodium sulfate to obtain 54g of compound 2 (2,3-dihydro-4-trichloroacetylfuran), with a yield of 86.08% and a purity of 98%.

References:

CN115433194,2022,A Location in patent:Paragraph 0034-0039; 0045-0049; 0058-0062; 0067-0071