2,3-DIHYDRO-5H-OXAZOLO[2,3-B]QUINAZOLIN-5-ONE synthesis

14synthesis methods

Product Name:2,3-DIHYDRO-5H-OXAZOLO[2,3-B]QUINAZOLIN-5-ONE
CAS Number:52727-44-3
Molecular formula:C10H8N2O2
Molecular Weight:188.18

3-(2-CHLOROETHYL)-2,4(1H,3H)-QUINAZOLINEDIONE

5081-87-8
71 suppliers
$40.00/100mg

2,3-DIHYDRO-5H-OXAZOLO[2,3-B]QUINAZOLIN-5-ONE

52727-44-3
35 suppliers
$45.00/50mg

Yield:52727-44-3 100%

Reaction Conditions:

with sodium carbonate in acetonitrile at 85; for 7 h;Reagent/catalyst;Temperature;

Steps:

4 step 4

Intermediate 03 (10.2g), sodium carbonate (4.8g), acetonitrile (100mL), heated at 85°C for 7h. After the completion of the reaction, it was filtered while hot to remove inorganic salts, and the filtrate was evaporated to dryness to obtain 8.5 g of a white solid product, with a yield=100%

References:

CN112142760,2020,A Location in patent:Paragraph 0045-0046; 0054-0058

77093-92-6 Synthesis