2,3-dihydroxypropyl benzoate synthesis

2synthesis methods

Product Name:2,3-dihydroxypropyl benzoate
CAS Number:3376-59-8
Molecular formula:C10H12O4
Molecular Weight:196.2

1,3-Dioxolane-4-methanol, 2,2-dimethyl-, 4-benzoate

98760-27-1
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3376-59-8
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$109.00/100mg

Yield:3376-59-8 98.7%

Reaction Conditions:

with hydrogenchloride in ethanol at 20; for 18 h;

Steps:

2j.B Step B: 2,3-dihydroxypropyl benzoate

The mixture of 20 g of the product from Step A (80 mmol, 1 eq.), 220 mL of a 1 N solution of HCl, and 220 mL of EtOH was stirred at rt for 18 h. After the reaction was quenched with cc. Na₂CO₃ and concentrated, the residue was extracted with EtOAc. The combined organic phases were washed with brine and dried to give 15.48 g (98.7%) of the desired product. 1H NMR (400 MHz, DMSO-d₆) d ppm 8.00 (dd, 2H), 7.67 (tt, 1H), 7.54 (t, 2H), 5.03 (d, 1H), 4.71 (t, 1H), 4.30 (dd, 1H), 4.17 (dd, 1H), 3.79 (sx, 1H), 3.45 (m, 2H).

References:

WO2021/18857,2021,A1 Location in patent:Page/Page column 60-61

1,2-Propanediol, 3-(triphenylmethoxy)-, 1-benzoate, (2R)-

20834-13-3
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3376-59-8
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$109.00/100mg

References