ChemicalBook CAS DataBase List 2,3-DIMETHYL-6-QUINOXALINAMINE

2,3-DIMETHYL-6-QUINOXALINAMINE synthesis

4synthesis methods

Product Name:2,3-DIMETHYL-6-QUINOXALINAMINE
CAS Number:7576-88-7
Molecular formula:C10H11N3
Molecular Weight:173.21

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7576-88-7
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Yield:7576-88-7 93%

Reaction Conditions:

with 5% Pd(II)/C(eggshell);hydrogen in ethanol at 20;

Steps:

General Procedure of 6-amino-quinoxalines 4.

General procedure: 6-Nitro-quinoxaline (3, 5mmol) was hydrogenated in the presence of 5% Pd/C (50 mg) under at room temperature in ethanol (30 ml) for 6-10 h. After the reaction 2 ml DMSO was added to the mixture and filtered. The filtrate was poured into water (200 ml) and the precipitate was filtered to give 6-amino-quinoxaline (4a-d) (90-95%).

References:

Chen, Qianyi;Bryant, Vashti C.;Lopez, Hernando;Kelly, David L.;Luo, Xu;Natarajan, Amarnath [Bioorganic and Medicinal Chemistry Letters,2011,vol. 21,# 7,p. 1929 - 1932] Location in patent:supporting information; experimental part

99-56-9 Synthesis