ChemicalBook CAS DataBase List 2 3-DIPALMITOYL-SN-GLYCEROL*

2 3-DIPALMITOYL-SN-GLYCEROL* synthesis

5synthesis methods

Product Name:2 3-DIPALMITOYL-SN-GLYCEROL*
CAS Number:6076-30-8
Molecular formula:C35H68O5
Molecular Weight:568.91

Hexadecanoic acid, 1,1'-[(1R)-1-[(phenylmethoxy)methyl]-1,2-ethanediyl] ester

90365-30-3
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6076-30-8
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Yield:6076-30-8 97%

Reaction Conditions:

with hydrogen;palladium 10% on activated carbon in ethyl acetate; under 37503.8 Torr; for 24 h;

Steps:

The aforementioned benzyl-protected compound (5.00 g) was dissolved in ethyl acetate (50 mL). The solution was added with 10% palladium/carbon (0.2 g), and the mixture was stirred for 1 day under a hydrogen atmosphere (5 MPa). After the catalyst was separated by filtration, the solvent was removed to obtain 1,2-dipalmitoyl glyceride (4.19 g, yield: 97%). ¹H-NMR (300MHz, CDCl₃) δ : 5.08 (1H, quin) 4.32 (1H, dd) 4.24 (1H, dd) 3.73 (2H, t) 2.33 (4H, q) 1.67-1.57 (4H, m) 1.33-1.22 (48H, m) 0.88(6H, t)

References:

EP1795208,2007,A1 Location in patent:Page/Page column 14