2-(3-FLUORO-PHENYL)-BENZOOXAZOLE synthesis
11synthesis methods
- Product Name:2-(3-FLUORO-PHENYL)-BENZOOXAZOLE
- CAS Number:20000-61-7
- Molecular formula:C13H8FNO
- Molecular Weight:213.21
Yield:20000-61-7 86%
Reaction Conditions:
with NHC-Pd(II)-Im;lithium tert-butoxide in toluene at 130; for 24 h;Inert atmosphere;Time;
Steps:
21 A method for arylation of benzoxazole, comprising the steps of:
General procedure: Under the protection of inert gas,Benzooxazole 1a,P-toluenesulfonate 2a,Azacyclocarbene-palladium complex 4,Lithium tert-butoxide,Toluene mix,The reaction liquid was obtained by reacting at 120 ° C for 12 hours.Then the reaction solution is post-treated to obtain a product.That is, 2-arylbenzoxazole 3a is obtained, wherein:
References:
CN108658886,2018,A Location in patent:Paragraph 0058
