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2-(3-METHOXY-2-METHYLPHENYL)ACETIC ACID synthesis

9synthesis methods
-

Yield:33797-36-3 97%

Reaction Conditions:

Stage #1: 2-(3-methoxy-2-methylphenyl)acetonitrilewith sodium hydroxide in ethanol;water; for 48 h;Reflux;
Stage #2: with hydrogenchloride in water; pH=2;

References:

Taylor, Simon J.;Demont, Emmanuel H.;Gray, James;Deeks, Nigel;Patel, Aarti;Nguyen, Dung;Taylor, Maxine;Hood, Steve;Watson, Robert J.;Bit, Rino A.;McClure, Fiona;Ashall, Holly;Witherington, Jason [Journal of Medicinal Chemistry,2015,vol. 58,# 20,p. 8236 - 8256]