2-(3-Methoxy phenyl)furan synthesis

10synthesis methods

Product Name:2-(3-Methoxy phenyl)furan
CAS Number:35461-93-9
Molecular formula:C11H10O2
Molecular Weight:174.2

13331-23-2 Synthesis

13331-23-2
339 suppliers
$13.43/250mgs:

2398-37-0 Synthesis

2398-37-0
574 suppliers
$8.00/10g

35461-93-9
30 suppliers
$86.00/100mg

Yield:35461-93-9 97%

Reaction Conditions:

with tetrakis(triphenylphosphine) palladium⁽⁰⁾;caesium carbonate in methanol;toluene at 100; for 16 h;Inert atmosphere;

Steps:

General procedure B: Synthesis of 2-aryl furans

General procedure: According to a procedure by Oxford et al.,^[3] furan-2-boronic acid (168 mg, 1.5 mmol, 1.5 eq), aryl halide (1.0 mmol, 1.0 eq), Pd(PPh₃)₄ (116 mg, 0.1 mmol, 10 mol%) and cesium carbonate (350 mg, 1.1 mmol, 1.1 eq) were suspended in a toluene/MeOH mixture (4:1, 10 mL). The reaction mixture was stirred for 16 h at 100 °C. The reaction mixture was diluted with EtOAc (8 mL) and the organic layer was extracted was washed with brine (20 mL), dried over Na₂SO₄, filtered and concentrated under reduced pressure. The crude product was purified by flash column chromatography.

References:

Ernst, Johannes B.;Rakers, Lena;Glorius, Frank [Synthesis,2017,vol. 49,# 2,art. no. SS-2016-T0511-OP,p. 260 - 268] Location in patent:supporting information

584-12-3 Synthesis