2,3-O-ISOPROPYLIDENE-1-O-METHYL-D-RIBOSIC ACID synthesis

Yield: 100%

Reaction Conditions:

Stage #1:((3aR,4R,6R,6aR)-6-methoxy-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methanol with sodium hypochlorite;tetrabutylammomium bromide;sodium bromide;2,2,6,6-tetramethyl-piperidine-N-oxyl;sodium hydrogencarbonate in dichloromethane at 0 - 20; for 1 h;
Stage #2: with sodium chlorite;sodium dihydrogenphosphate;2-methyl-but-2-ene in tetrahydrofuran;water;tert-butyl alcohol at 20;Further stages.;

References:

Huang, Lijun;Teumelsan, Nardos;Huang, Xuefei [Chemistry - A European Journal,2006,vol. 12,# 20,p. 5246 - 5252]