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3208-40-0

2-(3-PHENYLPROPYL)TETRAHYDROFURAN synthesis

5synthesis methods
From β-[2-(5-phenyl furyl)]-propionic acid butyl ester by catalytic hydrogenation with copper chromite under pressure and subsequent ring closure by heating the intermediate, 7-phenylheptan-1,4-diol, in the presence of Al2O3.
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Yield:3208-40-0 92%

Reaction Conditions:

with nickel(II) bromide ethylene glycol dimethyl ether;Potassium phosphate, dibasic;benzaldehyde;4,4'-di-tert-butyl-2,2'-bipyridine for 96 h;Catalytic behavior;Inert atmosphere;UV-irradiation;Reagent/catalyst;

References:

Zhang, Lumin;Si, Xiaojia;Yang, Yangyang;Zimmer, Marc;Witzel, Sina;Sekine, Kohei;Rudolph, Matthias;Hashmi, A. Stephen K. [Angewandte Chemie - International Edition,2019,vol. 58,# 6,p. 1823 - 1827][Angew. Chem.,2019,vol. 131,p. 1837 - 1841,5] Location in patent:supporting information