2,3-Piperazinedione,1-propyl-(9CI) synthesis
1synthesis methods
- Product Name:2,3-Piperazinedione,1-propyl-(9CI)
- CAS Number:59702-32-8
- Molecular formula:C7H12N2O2
- Molecular Weight:156.18
Yield:59702-32-8 2.32 g
Reaction Conditions:
in ethanol; for 18 h;Reflux;
Steps:
51.1 Step 1. Synthesis of l-propylpiperazine-2,3-dione.
To N-propylethylenediamine (1.95 g, 19 mmol) in EtOH (35 mL) was added diethyl oxalate (2.8 mL, 20.6 mmol). The reaction mixture was stirred at reflux for 18 h, then concentrated in vacuo, the residue was purified by flash chromatography on silica gel (DCM-MeOH,30: 1-6: 1) to afford the product, 2.32 g. ESI-MS m/z 157 (MH)+.
References:
WO2018/218190,2018,A1 Location in patent:Paragraph 00249