2,4(1H,3H)-Pyrimidinedione, 6-ethyl- (9CI) synthesis
- Product Name:2,4(1H,3H)-Pyrimidinedione, 6-ethyl- (9CI)
- CAS Number:15043-03-5
- Molecular formula:C6H8N2O2
- Molecular Weight:140.14
Yield:15043-03-5 86%
Reaction Conditions:
with boron trifluoride diethyl etherate at 135; for 0.0833333 h;Neat (no solvent);Microwave irradiation;
Steps:
Synthesis using BF3 (1-5):
General procedure: A β-ketoester (1a-5a, 2 mmol), taken in a reactor vessel with BF3 Et2O (339mg, 2.4mmol) was mixed thoroughly for 1 min with urea (156mg, 2.6mmol). The vessel was closed immediately and was subjected to microwave irradiation at 135°C. The compound (1-5) was further purified by column chromatography. Yield: as shown in table-1
References:
Burgula, Laxmi Narayana;Radhakrishnan;Kundu, Lal Mohan [Tetrahedron Letters,2012,vol. 53,# 21,p. 2639 - 2642] Location in patent:supporting information; experimental part
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