![](/CAS/GIF/83616-07-3.gif)
2,4,4'-TRIHYDROXY BENZALACETOPHENONE synthesis
- Product Name:2,4,4'-TRIHYDROXY BENZALACETOPHENONE
- CAS Number:83616-07-3
- Molecular formula:C15H12O4
- Molecular Weight:256.25
![(E)-3-(2,4-dimethoxyphenyl)-1-(4-methoxyphenyl)prop-2-en-1-one](/CAS/20180601/GIF/24533-49-1.gif)
24533-49-1
4 suppliers
inquiry
![2,4,4'-TRIHYDROXY BENZALACETOPHENONE](/CAS/GIF/83616-07-3.gif)
83616-07-3
10 suppliers
inquiry
Yield:83616-07-3 78%
Reaction Conditions:
with boron tribromide in dichloromethane at 0 - 20; for 24 h;Inert atmosphere;
Steps:
3. Demethylation using BBr3: General Procedure
General procedure: The correspondingmethoxy substituted chalcones (0.25 mmol) obtained from the previous step (1) were dissolved in dried CH2Cl2(15 mL) and cooled down to 0oC. BBr3 (2 equiv per anypotentially basic Nor O) was slowly added to the reaction mixture kept under N2atmosphere. After stirring for 24h at room temperature, the reaction was cooledto 0oC and quenched with a very slow addition of H2O. Theresulting red solids were separated by filtration and washed with H2Oand CH2Cl2. The crude product was further purified bycolumn chromatography over Si gel using 20% MeOH in CH2Cl2to afford the hydroxyl chalcones.
References:
Nijampatnam, Bhavitavya;Casals, Luke;Zheng, Ruowen;Wu, Hui;Velu, Sadanandan E. [Bioorganic and Medicinal Chemistry Letters,2016,vol. 26,# 15,p. 3508 - 3513] Location in patent:supporting information
![2,4-Dihydroxybenzaldehyde](/CAS/GIF/95-01-2.gif)
95-01-2
484 suppliers
$10.00/1g
![2,4,4'-TRIHYDROXY BENZALACETOPHENONE](/CAS/GIF/83616-07-3.gif)
83616-07-3
10 suppliers
inquiry