2,4,5-TRIFLUORO-3-HYDROXYBENZOIC ACID METHYL ESTER synthesis
- Product Name:2,4,5-TRIFLUORO-3-HYDROXYBENZOIC ACID METHYL ESTER
- CAS Number:137234-92-5
- Molecular formula:C8H5F3O3
- Molecular Weight:206.12
116751-24-7
179 suppliers
$10.00/1g
616-38-6
676 suppliers
$5.00/5G
136897-64-8
88 suppliers
$80.00/1g
137234-92-5
12 suppliers
$377.00/10g
Yield:137234-92-5 91%
Reaction Conditions:
with potassium iodide in N,N-dimethyl acetamide;water;
Steps:
3 Example 3
Example 3 38.4 g (0.2 mol) of 3-hydroxy-2,4,5-trifluorobenzoic acid, 1.2 g of potassium iodide and 2 g of dibenzo-18-crown-6 and 20 g (0.22 mol) of dimethyl carbonate are dissolved in 250 g of N,N-dimethylacetamide with stirring, the mixture is transferred to an autoclave lined with PTFE, heated to 110° C. with stirring and allowed to react for 18 hours. According to GC, the reaction product does not contain any starting material and only <1% of methyl 3-methoxy-2,4,5-trifluorobenzoate. Excess solvent is distilled off through a short Vigreux column, the remaining oily residue is subjected to fractional distillation, and the substance obtained is stirred with 300 g of hot water. This gives 37.6 g (0.183 mol) of methyl 3-hydroxy-2,4,5-trifluorobenzoate. (91% yield; purity by GC >99%).
References:
US5430173,1995,A
116751-24-7
179 suppliers
$10.00/1g
136897-64-8
88 suppliers
$80.00/1g
137234-92-5
12 suppliers
$377.00/10g
67-56-1
746 suppliers
$9.00/25ml
116751-24-7
179 suppliers
$10.00/1g
137234-92-5
12 suppliers
$377.00/10g
116751-24-7
179 suppliers
$10.00/1g
137234-92-5
12 suppliers
$377.00/10g
79-37-8
465 suppliers
$17.67/10gm:
116751-24-7
179 suppliers
$10.00/1g
137234-92-5
12 suppliers
$377.00/10g