2,4,5-TRIFLUOROBENZENESULFONAMIDE synthesis

Yield:287172-63-8 98%

Reaction Conditions:

with ammonium hydroxide in tetrahydrofuran at 20;

Steps:

13.1 Step 1: 2,4,5-trifluorobenzenesulfonamide

To a solution of 2,4,5-trifluorobenzene-1-sulfonyl chloride (3.0 g, 13 mmol), in THF(30 mL) was added NH4OH (910 mg, 26 mmol) and the solution was stirred for 14 h at rt. The solution was concentrated in vacuo to afford 2,4,5-trifluorobenzenesulfonamide (2.7 g, 13 mmol, 98%) as a yellow solid. ESI-MS (EI+, m/z): 211.9 [M+H]t

References:

WO2018/89433,2018,A1 Location in patent:Paragraph 00411