![](/CAS/GIF/214759-21-4.gif)
2,4,6-TRIFLUOROBENZYL AMINE synthesis
- Product Name:2,4,6-TRIFLUOROBENZYL AMINE
- CAS Number:214759-21-4
- Molecular formula:C7H6F3N
- Molecular Weight:161.12
![2,4,6-Trifluorobenzonitrile](/CAS/GIF/96606-37-0.gif)
96606-37-0
233 suppliers
$6.00/1g
![2,4,6-TRIFLUOROBENZYL AMINE](/CAS/GIF/214759-21-4.gif)
214759-21-4
207 suppliers
$9.00/250mg
Yield:214759-21-4 94%
Reaction Conditions:
with ammonia;hydrogen in isopropyl alcohol at 65 - 75; under 7500.75 Torr;Reagent/catalyst;Temperature;
Steps:
12 Example 12: Preparation of 2,4,6-trifluorobenzylamine
Raney Nickel (8 gm) and 2-propanol (550 gm) were charged into a reactor. The reactor was flushed once with nitrogen and then with hydrogen. The reaction mixture was heated to 65- 75°C. Hydrogen was charged in reactor at 65-75°C continuously to 10 kg/cm2. Anhydrous ammonia was charged in the reactor at 65-75°C. A solution of 2,4,6-trifluorobenzonitrile (15% in 2-propanol) was charged in the reactor using a HPLC pump at a rate of 0.5-2ml/min in 10-12 hours. After completion of the reaction, the reaction mass was cooled to 20-25°C and residual pressure was released. Reaction mass was filtered, washed with 2-propanol (200 gm). The filtrate was concentrated and purified by distillation under reduced pressure Yield (%): 94%; Purity (by GC): 97%
References:
SRF LIMITED;SINGH, Amardeep;SINGH, Bhupender;SINGH, Ram;KUMAR, Rajender;CHAUDHARY, Ajay Kumar;KUMAR, Kapil;JAIN, Anurag WO2020/152711, 2020, A1 Location in patent:Page/Page column 16-17
![3,5-Dichloro-2,4,6-trifluorobenzonitrile](/CAS/20200401/GIF/31881-89-7.gif)
31881-89-7
9 suppliers
inquiry
![2,4,6-TRIFLUOROBENZYL AMINE](/CAS/GIF/214759-21-4.gif)
214759-21-4
207 suppliers
$9.00/250mg
![Pentachlorobenzonitrile](/CAS/GIF/20925-85-3.gif)
20925-85-3
187 suppliers
$6.00/1g
![2,4,6-TRIFLUOROBENZYL AMINE](/CAS/GIF/214759-21-4.gif)
214759-21-4
207 suppliers
$9.00/250mg
![1,3,5-Trifluorobenzene](/CAS/GIF/372-38-3.gif)
372-38-3
307 suppliers
$9.00/1g
![2,4,6-TRIFLUOROBENZYL AMINE](/CAS/GIF/214759-21-4.gif)
214759-21-4
207 suppliers
$9.00/250mg
![2,4,6-Trifluorobenzaldehyde](/CAS/GIF/58551-83-0.gif)
58551-83-0
205 suppliers
$8.00/1g
![2,4,6-TRIFLUOROBENZYL AMINE](/CAS/GIF/214759-21-4.gif)
214759-21-4
207 suppliers
$9.00/250mg